SCIENTIFIC PROGRAMS AND ACTIVITIES

February 20, 2025

THE FIELDS INSTITUTE FOR RESEARCH IN MATHEMATICAL SCIENCES

July 17-18 2015
2nd Workshop on Virus Dynamics

Fields Institute, 222 College St,Toronto

Organizers:
Catherine Beauchemin, Ryerson University
Udo Reichl, Max Planck Institute for Dynamics of Complex Technical Systems

Online registration is now closed Onsite registration will be available
Fees: $120. Students and PDFs $60
Invited speakers fees waived.
Dinner tickets $65 per person.

Online registration until to July 12.
Onsite registration available on July 17.

Abstract Submission closed on
April 1st, 2015.

Reimbursement information for funded participants
Information for speakers Map to Fields Accommodation in Toronto

Overview

The modelling of infectious disease spread at the multi-host level (epidemiology) has garnered a lot of attention, and has attracted a large community of researchers with significant, dedicated funding programmes. In contrast, the community of researchers working on models of disease spread at the single cell, cell culture, organ or single-host level (virology, immunology), an equally important and complementary aspect of disease control and eradication, is much smaller, and distributed around the world. Nonetheless, several of us are working on related problems and have benefited significantly from the 1st Workshop on Virus Dynamics which was held in Summer 2013 in Frankfurt, Germany.

The objective of this year's 2-day workshop is to build on the success of the 1st workshop and to further discuss the present state and future development in modelling virus dynamics from the single-cell level up to the level of a single host. Participants will discuss their progress in developing optimal experimental systems plus mathematical and computational modelling platforms which, when combined, enable them to extract the key parameters characterizing viral replication in vitro or in vivo. The topics covered at this year's workshop will include the comparison of local virus spread via direct, cell-to-cell transfer versus distal spread by release and diffusion of free virions, the effect of stochasticity at low virus concentration during early infection and its possible long-term impact on progress of infection, the emergence and growth kinetics of defective interfering particles and the artifacts it could introduce in commonly used experimental systems, and the role of host and immune factors in controlling or arresting the infection.

Schedule

Friday July 17, 2015.
8:30-8:40
Open/Intro
8:40-9:20 Keynote: Alan S Perelson, Modeling HIV cure
9:20-9:45 Jessica M. Conway, Residual viremia in treated HIV+ patients: simple model insights
9:45-10:05 Xiaodan Sun, Personalized life expectancy and treatment benefit index of antiretroviral therapy
10:05-10:25
Coffee Break
10:25-11:05 Keynote: Vitaly V. Ganusov, Insights from mathematical modeling of wthin-host dynamics and evolution of SIV and HIV
11:05-11:30 Shinji Nakaoka, Dynamics of HIV infection in a lymph-node network
11:30-11:55 Frederic Bertels, Parallel evolution of HIV-1 in a long term experiment
11:55-12:15 Yusuke Kakizoe, A method to determine the duration of the eclipse phase for SHIV-KS661 virus infection experiment in vitro
12:15-13:40
Lunch Break
13:40-14:20 Keynote: Shingo Iwami, Quantifying combination activity of anti-HCV drugs in vitro
14:20-14:45 Harel Dahari, Individualized IFN free therapy via real-time mathematical modeling of HCV kinetics
14:45-15:10 Jeremie Guedj, The paradox of highly effective sofosbuvir-based combination therapy despite slow viral decline
15:10-15:30
Coffee Break
15:30-15:55 Frederik Graw, Quantification of HCV cell-to-cell spread using a stochastic modelling approach
15:55-16:15 Peter Kumberger, Modes of viral transmission and their implications - Analyzing the spread of HCV
16:15-16:40 Kenneth Blahut, Quantifying the relative contribution of free virus vs. cell-to-cell infection of hepatitis C virus in vitro
16:40-17:05 Amber M. Smith, In Vivo Kinetics of Sendai Virus Infection
19:00-22:00
Dinner: Via Mercanti (registration required)

***

Saturday July 18, 2015.
9:00-9:40 Keynote: Thomas Höfer, Propogation of dengue virus in interferon-competent cells
9:40-10:05 Melanie Rinas, Single-cell analysis and data-driven modeling identify major determinants attenuating a vaccine candidate Dengue virus mutant
10:05-10:25
Coffee Break
10:25-11:05 Keynote: John Yin, Dual-color reporting of virus growth and infection spread
11:05-11:30 Anton Zilman, Specificity and adaptation in Type I interferon signaling
11:30-11:55 Tanja Laske, Analyzing the dynamics of influenza A virus replication in the presence of defective interfering RNA
11:55-12:20 Laura Liao, (In)validating experimentally-acquired knowledge about influenza A defective interfering particles
12:20-13:50
Lunch Break
13:50-14:10 Benjamin Holder, Addressing an early-time discrepancy between in vitro influenza infections and model dynamics
14:10-14:35 Laetita Canini, Modelling respiratory symptoms dynamics of influenza A in humans: Towards a quantitative undersatnding of infectiousness
14:35-14:55 Chris Hadjichrysanthou, Using simple mathematical models to understand the within-host dynamics of influenza A infection: From theory to clinical implications
14:55-15:15
Coffee Break
15:15-15:35 Hana Dobrovolny, Comparison of in vitro influenza and RSV kinetics parameters
15:35-15:55 Elissa J. Schwartz, Identifying the Conditions under which Antibodies Protect Against Infection by Equine Infectious Anemia Virus
15:55-16:15 Carmen Lia Murall, Investigating the evolutionary ecology of Human papillomavirus using within-host models
16:15
Wrap-up
 
Casual Dinner/Drinks

 

Format

The two-day workshop will tentatively be divided into:

• Five keynote talks, 35 min each + 5 min questions
• 13 talks by participants, 20 min each + 5 min questions
• 7 talks by participants, 15 min each + 5 min questions

which will fall under one or more of the following topics:


Topic 1 - Virus replication in vitro at the intracellular and intercellular level
Topic 2 - Viral infection kinetics in vivo
Topic 3 - Host/immune responses, antiviral therapy, and drug resistance


The complete conference programme is currently under construction and will be provided shortly.

Confirmed keynote speakers

Prof. Vitaly Ganusov (University of Tennessee-Knoxville, USA)
Prof. Thomas Höfer (Universität Heidelberg/German Cancer Research Center DKFZ, Germany)
Prof. Shingo Iwami (Kyushu University, Japan)
Prof. Alan S. Perelson (Los Alamos National Laboratory, USA)
Prof. John Yin (University of Wisconsin-Madison, USA)


Accommodation warning

The workshop will be held at the same time as the following popular Toronto events
Pan American Games, July 10-26, 2015
Beaches International Jazz Festival, July 17-26, 2015
for this reason, we suggest that you book your accommodation as early as possible.

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