Systems Modeling in the Pharmaceutical Industry - Problem Solving Workshop
Description
Funding application closed: March 31, 2019
This workshop aims to equip graduate students and postdoctoral fellows in mathematics and related disciplines with the tools necessary to solve common problems encountered in the pharmaceutical industry. The focus will be on development of pharmacometric skills to approach questions centred on drug development and dose/therapy optimization using a variety of state-of-the-art quantitative systems pharmacology (QSP) methodologies, also known as systems modeling. Participants will receive training in QSP approaches, including the principles of pharmacokinetics and pharmacodynamics (PK/PD), from academic and industrial researchers, and will apply these techniques in groups to solve a set of problems brought by industry partners. At the end of the week, participants will be able to identify the main components of a pharmaceutical problem through a QSP lens, translate these elements mathematically, analyze/numerically implement and solve the resulting mathematical model, and deliver results (visually and textually) to non-mathematicians. Ultimately, participants will gain understanding into the factors that are key to mathematical modeling in the pharmaceutical industry and be trained in modern QSP approaches.
Problems
Problem Title | Project Leader | Affiliation |
Dose selection rationale for type 1 interferon neutralizing antibody | Timothy Nicholas | Pfizer |
Response threshold analysis in exposure-response and pharmacogenetic translational applications | Bart Borek | Vertex |
Cardiovascular QSP Modeling: Virtual Ventricular Cell Case Study | Anna Kirpichnikova | University of Stirling |
Immuno-oncology: Evaluating Strategies for overcoming rituximab resistance via modulation of Antibody-Dependent Cell-mediated Cytotoxicity & Phagocytosis (ADCC & ADCP) | Dean Bottino | Takeda |
Sponsors
Applied BioMath
International Society of Pharmacometrics
Metrum
Pfizer
Individual Donor
Schedule
09:00 to 11:00 |
Intro to pharmacokinetics/pharmacodynamics
Morgan Craig, Université de Montréal, Timothy Nicholas, Pfizer Inc. |
11:00 to 11:20 |
Coffee break
|
11:20 to 12:30 |
Intro to QSP
C.J. Musante, Pfizer Inc. |
12:30 to 14:00 |
Lunch
|
14:00 to 14:15 |
Problem Presentation: Dose selection rationale for type 1 interferon neutralizing antibody
Timothy Nicholas, Pfizer Inc. |
14:20 to 14:35 |
Problem Presentation: Response threshold analysis in exposure-response and pharmacogenetic translational applications
Bart Borek, Vertex Pharmaceuticals |
14:40 to 14:55 |
Problem Presentation: Cardiovascular QSP Modeling: Virtual Ventricular Cell Case Study
Anna Kirpichnikova, University of Stirling |
15:00 to 15:15 |
Problem Presentation: Immuno-oncology: Evaluating Strategies for overcoming rituximab resistance via modulation of Antibody-Dependent Cell-mediated Cytotoxicity & Phagocytosis (ADCC & ADCP)
Dean Bottino, Takeda Pharmaceuticals |
15:15 to 15:30 |
Coffee break
|
15:30 to 17:00 |
Breakout into groups for preliminary discussions
|
17:00 to 19:00 |
Reception
|
09:00 to 11:00 |
Matlab for QSP
|
11:00 to 11:20 |
Coffee break
|
11:20 to 12:30 |
Breakout into groups
|
12:30 to 14:00 |
Lunch
|
14:00 to 15:15 |
Breakout into groups
|
15:15 to 15:30 |
Coffee break
|
15:30 to 17:00 |
Breakout into groups
|
17:00 to 17:30 |
Whole group meets to give summaries of progress
|
09:00 to 11:00 |
Intro to physiologically-based pharmacokinetics
Paul Malik, University of Waterloo |
11:00 to 11:20 |
Coffee break
|
11:20 to 12:30 |
Breakout into groups
|
12:30 to 14:00 |
Lunch
|
14:00 to 15:15 |
Breakout into groups
|
15:15 to 15:30 |
Coffee break
|
15:30 to 17:00 |
Breakout into groups
|
17:00 to 17:30 |
Whole group meets to give summaries of progress
|
09:00 to 11:00 |
Breakout into groups
|
11:00 to 11:20 |
Coffee break
|
11:20 to 12:30 |
Breakout into groups
|
12:30 to 14:00 |
Lunch
|
14:00 to 15:15 |
Breakout into groups
|
15:15 to 15:30 |
Coffee break
|
15:30 to 17:00 |
Breakout into groups
|
17:00 to 17:30 |
Whole group meets to give summaries of progress
|
09:00 to 11:00 |
Finalize reports/presentations
|
11:00 to 11:20 |
Coffee break
|
11:20 to 11:50 | |
12:00 to 12:30 | |
12:30 to 14:00 |
Lunch
|
14:00 to 14:30 | |
14:30 to 15:00 | |
15:00 to 15:15 |
Wrap-up
|