Draft Program (speaker abstracts)
| Monday, July 7 | |
| TIME | Cortical Spreading Depression: History - Medicine - Mathematics |
|
8:45-9:00 |
Welcome |
|
9:00-9:45 |
Bernice Grafstein Spreading depression as a holistic process: A historical perspective (slides) |
|
10:00-10:45 |
Cenk Ayata Spreading depression and the biological heterogeneity of cerebral blood flow response: clues for modeling |
|
11:00-11:30 |
Coffee break |
|
11:30-12:15 |
Huaxiong Huang Modeling cortical spreading depression and related phenomena |
|
12:30-2:00 |
Lunch break |
|
2:00-2:45 |
Steven Schiff Unification in the Observation and Control of Spikes, Seizures, and Spreading Depression |
|
3:00-3:30 |
Tea break |
| 3:30-4:00 | Jess Seidel (slides) |
|
4:00-6:00 |
DISCUSSION
|
| Tuesday, July 8 | |
| CSD related phenomena | |
| 9:00-9:45 | David Terman Blocking spreading depolarizations in a neuron/astrocyte network model |
| 10:00-10:45 | Jed Hartings Spreading depolarizations in acute brain injury: mathematical dynamic instability of cerebral cortex? |
| 11:00-11:30 | Coffee break |
| 11:30-12:15 | Béla Joós The Nav coupled left shift model of axon damage: how minor damage can cause major grief |
| 12:30-2:00 | Lunch break |
| 2:00-2:45 | Ghanim Ullah Towards a model-based control of neuronal systems |
| 3:00-3:30 | Tea break |
| 3:30-4:00 | Jorge Mendez |
| 4:00-6:00 | Workshops (single or parallel, presented on Thursday) |
| Wednesday, July 9 | |
| Simplifying models | |
| 9:00-9:45 | Ernest Barreto Ion Concentration Dynamics and its Effects on Neuronal Excitability and Bursting |
| 10:00-10:45 | Bas-Jan Zandt Dynamics of single neurons and populations during spreading depolarization |
| 11:00-11:30 | Coffee break |
| 11:30-12:15 |
Niklas Hübel |
| 12:30-2:00 | Lunch break |
| 2:00-2:45 | Markus A. Dahlem Ghost behavior: Transient localized patterns of CSD in the gyrified human cortex (slides) |
| 3:00-3:30 | Tea break |
| 3:30-4:00 | KC Brennan |
| 4:00-6:00 | Workshops (single or parallel, presented on Thursday) |
| Thursday, July 10 | |
| Minimal conditions: from nucleation to thresholds and susceptibility | |
| 9:00-9:45 | Frederike Kneer (ABSTRACT) Nucleation, front and pulse propagation in reaction-diffusion models |
| 10:00-10:45 | K.C. Brennan Minimum conditions for the induction of CSD |
| 11:00-11:30 | Coffee break |
| 11:30-12:15 | David Andrew Spreading depolarization strength during ischemia determines higher brain susceptibility and lower brain resistance to acute injury |
| 12:30-2:00 | Lunch |
| 2:00-3:00 | Edward Dudek |
| 3:00-3:30 | Tea break |
| 3:30-4:00 | Yoichiro Mori |
| 4:00-6:00 | Workshop teams Presentation of main workshop resolutions (continued) |
| Friday, July 11 | |
| 9:00-10:00 | Late breaking news Open slot |
| 10:00-10:45 | Closing session 1: Where do we go from here - Special issue and next workshops |
| 11:00-12:00 | Closing session 2: Funding - Canada, USA, Europe, and other |
| 12:00 | Farewell and goodbye |
Frederike Kneer
Nucleation, front and pulse propagation in reaction-diffusion models
To describe CSD by an effective model that also allows for analytical approximations, we study reaction-diffusion waves on curved two-dimensional surfaces and determine the influence of curvature upon the nucleation and propagation of spatially localized waves in an excitable medium modelled by the generic FHN model. We show, that the stability of propagating wave segments crucially depends on the curvature of the surface. Besides, to get deeper insight in biophysical processes involved in CSD, an ion-based Hodgkin-Huxley-type model is used. Focussing on propagation of CSD, we describe spatial coupling by the assupmtion of extracellular diffusing potassium. We find, that this bistable model provides coexisting wave fronts and backs propagating with different velocities. Introducing glial potassium uptake into the model, phasespace structure changes. The hence monostable model has propagating pulse solutions.
