Abstract: Chern-Simons theory is a topological quantum field theory which leads to link invariants, such as the Jones polynomial, through the expectation values of Wilson loops. The same link invariants also appear in a mathematical construction of Reshetikhin and Turaev which uses a trace on Yang-Baxter operators. Several algebraic structures are involved in these frameworks for computing link invariants, including the braid group, quantum algebras and centralizer algebras (such as the Temperley-Lieb algebra). In this talk, I will explain how the Askey-Wilson algebra, originally introduced in the context of orthogonal polynomials, can also be understood within the Chern-Simons theory and the Reshetikhin-Turaev link invariant construction. For this purpose, I will present relevant aspects of knot theory and of both approaches for computing invariants, and I will provide some background on the Askey-Wilson algebra. The main point will then be to argue that this algebra can be interpreted in terms of certain tangle diagrams.