Existing universal quantum computers are noisy intermediate-scale quantum (NISQ) devices that are limited in the number of qubits, connectivity, and gates fidelity. As a result, the utility of such devices, for example, for quantum cryptography, is minuscule. However, certain applications, such as quantum chemistry calculations, can be made meaningful having merely 30–50 qubits and a few hundreds of gates available given a proper method tailored to both a specific application and quantum hardware requirements. In this lecture we discuss a method specifically dedicated for the use with NISQ computers: the iterative qubit coupled cluster method (iQCC). We shall review the iQCC method for ground-state optimization and properties.