The hippocampus, one of the most studied brain regions, has been implicated in the encoding and retrieval of episodic memories (declarative and spatial memories). Recent hippocampus research has yielded a wealth of data on network architecture, cell types, the anatomy and membrane properties of pyramidal cells and interneurons, and synaptic plasticity. Understanding the functional roles of the different families of hippocampal neurons in encoding and retrieval of memory patterns, synaptic plasticity and network oscillations poses a great challenge, but also promises deep insights into how the brain stores and recalls memories. Computational models play an instrumental role in providing clues on how these processes may take place. In my talk, I will present two computational models of hippocampal dynamics addressing the issues of memory capacity, recall performance and rate code and phase code in the hippocampus.

References

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Cutsuridis V, Hasselmo M. (2012). GABAergic modulation of gating, timing and theta phase precession of hippocampal neuronal activity during theta oscillations. Hippocampus, DOI: 10.1002/hipo.21002

Cutsuridis V, Graham BP, Cobb S. (2010). Encoding and retrieval in the hippocampal CA1 microcircuit model. Hippocampus, 20(3): 423-446