Journal Club - BOLT-LMM, a linear mixed model for GWAS
Speaker:
Changchang Xu (University of Toronto)
Date and Time:
Friday, March 29, 2019 - 10:00am to 12:00pm
Location:
Fields Institute, Stewart Library
Abstract:
Reading for Journal Club - BOLT-LMM, a linear mixed model for GWAS
Primary paper:
Loh et al (2018) "Mixed-model association for biobank-scale datasets"
https://www.ncbi.nlm.nih.gov/pubmed/29892013
https://www-nature-com.myaccess.library.utoronto.ca/articles/s41588-018-...
Background:
Loh et al (2015) "Efficient Bayesian mixed model analysis increases association power in large cohorts"
https://www.ncbi.nlm.nih.gov/pubmed/25642633
https://www-nature-com.myaccess.library.utoronto.ca/articles/ng.3190
Bulk-Sullivan et al (2015) "LD Score regression distinguishes confounding from polygenicity in genome-wide association studies"
https://www.ncbi.nlm.nih.gov/pubmed/25642630
https://www-nature-com.myaccess.library.utoronto.ca/articles/ng.3211
