The quasi-steady state approximation is frequently employed in mathematical biology to simplify complex nonlinear differential equations from both theoretical and experimental perspectives. Several studies have focused on identifying the parameter range for which this approximation can be effectively used, by deriving "roughly" valid sufficient conditions. In this seminar, we aim to delve deeper into the applicability and clarify the validity of the quasi-steady state approximation. Our exploration will pivot on the Michaelis–Menten reaction mechanism, a fundamental model for enzyme activity, as the case study.

Short Bio: Santiago Schnell FRSB FRSC is a scientist and academic leader, currently serving as the William K. Warren Foundation Dean of the College of Science at the University of Notre Dame, as well as a professor in the Department of Biological Sciences, and Department of Applied and Computational Mathematics and Statistics.